2016 Heart failure with reduced ejection fraction

 

Renin-angiotensin

      ACE

      ARB

      ARNI = ARB + neprilysin inhibitor

o   Entresto = valsartan + sacubitril

Beta blocker

      Bisoprolol (B1)

      Carvedilol (B1, B2, A1)

      Nebivolol (B1)

      Metoprolol XR

Mineralocorticoid receptor antagonist

      Spironolactone

      Eplerenone

Miscellaneous

      HCN antagonist (ivabradine): if HR >70

      SGLT2 inhibitor (-flozin): if T2DM

ICD

      AICD: if LVEF <35%

      Bi-V PPM: if LVEF <35% and very wide QRS

 

 

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