|
Question |
BIS vs routine |
|
Type |
· Multi-centre, double blinded RCT |
|
Subjects |
· High risk of awareness (e.g. cardiac, trauma, GA LUSCS) |
|
Upshot |
· ↓Awareness by 82%, NNT 138 |
|
Comments |
· >40% TIVA, stricter criteria |
|
Question |
BIS vs end-tidal |
|
Type |
· Single-centre, assessor-blinded RCT |
|
Subjects |
· High risk for awareness |
|
Groups |
· BIS 40-60 vs ETAC 0.7-1.3MAC |
|
Upshot |
· No difference (2 vs 2) |
|
Problems |
· Liberal inclusion criteria · Underpowered · Poor adherence · Single hospital · No TIVA by definition |
|
Question |
BIS vs end-tidal |
|
Type |
· Multi-centre, assessor-blinded RCT |
|
Subjects |
· High risk for awareness |
|
Groups |
· BIS 40-60 vs ETAC 0.7-1.3MAC |
|
Upshot |
· ↑Awareness in BIS group (7 vs 2) |
|
Comments |
· No TIVA by definition |
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