Question |
PCI/CABG pre-vascular surgery |
Type |
· Multi-centre RCT |
Upshot |
· ↔AMI · ↔Mortality |
Comments |
· High risk patients excluded (e.g. LMCA disease, LVEF <20%, severe AS) · 98% male |
Question |
Metoprolol in patients undergoing non-cardiac surgery |
Background |
· Discredited DECREASE studies supported peri-op b-blocker |
Type |
· Multi-national RCT |
Upshot |
· ↓Non-fatal AMI · ↑Significant bradycardia · ↑Significant hypotension · ↑Stroke · ↑Death |
Question |
TAVI vs AVR |
Type |
· Multi-centre, randomized parallel trial |
Subjects |
· Severe AS, high risk patients |
Upshot |
· ↔Composite all-cause mortality or major stroke · ↓Major bleeding · ↑Vascular complication |
Not sure which trials this stuff comes from |
· From multiple trials, TAVI… (I think) · ↓AKI · ↓New AF · ↓Major bleeding · ↓Mean valve gradient · · ↑Major vascular complications · ↑Pacemaker requirement · ↑Paravalvular regurgitation · ↑Re-intervention rate · · ↔Stroke · ↔Mortality |
Question |
TAVI vs nothing |
Type |
· Multi-centre, randomized parallel trial |
Subjects |
· Severe AS, inoperable |
Upshot |
· ↓All-cause mortality or major stroke at 1 year · ↓Readmission for valve at 1 year · ↑Vascular complications |
Question |
Peri-op aspirin |
Type |
· Multi-national, 2x2 factorial placebo-controlled RCT |
Subjects |
· Non-cardiac surgery |
Upshot |
· ↔Mortality · ↔AMI · ↑Major bleeding in those not already taking aspirin |
Question |
Peri-op low dose clonidine |
Upshot |
· ↔AMI · ↑Hypotension · ↑Non-fatal cardiac arrest |
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