|
Question |
Pulmonary artery catheter |
|
Type |
· ICU patients needing PAC (according to treating doctor) |
|
Subjects |
· PAC vs not |
|
Upshot |
· ↔Mortality · ↔Length of stay · Complications in 10% o Arterial puncture, haematoma o Pneumothorax, haemothorax o Arrhythmia |
|
Question |
Cardiac output guidance in major abdo surgery |
|
Type |
· Multinational, assessor-blinded RCT |
|
Subjects |
· High risk patients undergoing major abdo surgery |
|
Groups |
· LiDCO-guided fluid/dopexamine vs clinical; intra-op + 6 hours |
|
Upshot |
· ↔Mortality · ↔Complications |
|
Comments |
· Importance of statistically insignificant differences unclear · Updated meta-analysis suggests ↓complications |
|
Question |
Goal-directed haemodynamic therapy in low-moderate risk patients |
|
Type |
· Multi-centre RCT |
|
Subjects |
· Major elective surgery |
|
Groups |
· Oesophageal doppler vs not |
|
Targets for doppler group |
· SVV <10% · CI >2.5 · mAP >65 |
|
Upshot |
· ↓Moderate-to-severe complications (NNT 13) |
|
Comments |
· Underpowered · Several methodological weaknesses |
|
Question |
Aspirin for primary prevention |
|
Type |
· Multi-national double-blinded RCT |
|
Subjects |
· 70 years |
|
Groups |
· aspirin vs placebo |
|
Upshot |
· ↑Cancer-related death · ↑Major haemorrhage |
|
Question |
Cardiac output-guidance in major abdo surgery 2 |
|
Outcome |
· TBC |
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