|
Question |
Tidal volume in ARDS |
|
Background |
Old studies showed high VT reduces atelectasis |
|
Type |
Multi-centre RCT |
|
Subjects |
ARDS |
|
Groups |
New: VT 6mL/kg and Pplat <30cmH2O Old: VT 12mL/kg |
|
Upshot (new way) |
↓Mortality ↓Time on ventilator |
|
Question |
Proning in ARDS |
|
Type |
Multi-national RCT |
|
Subjects |
ARDS intubated >36 hours |
|
Groups |
Prone 16/24 vs supine 24/24 |
|
Upshot |
↓↓Mortality 50% ↔Adverse effects from proning |
|
Question |
High frequency oscillatory ventilation in ARDS |
|
Type |
Multi-national RCT |
|
Subjects |
Early ARDS |
|
Groups |
HFOV vs conventional |
|
Upshot |
↑↑Mortality -> study terminated early |
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