|
TRICC 1999 |
Hb 7-9 vs 10-12: in ICU Type: multi-centre RCT -↓Mortality in restrictive group -Doesn’t apply if active myocardial ischaemia |
|
FOCUS 2011 |
Hb 8 vs 10: hip fracture Type: multi-centre RCT -↔Mortality -↔Functional outcome |
|
TRISS 2014 |
Hb 7 vs 9: septic shock Type: multi-centre RCT -↔Mortality in restrictive group -↔Ischaemic events |
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Villaneuva 2013 |
Hb 7 vs 9: upper GI bleeding Type: single-centre RCT -↓Mortality in restrictive group |
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PROMMTT 2013 |
Ratios of RBC:FFP:plt – balanced vs RBC-heavy Type: prospective cohort study Upshot: <6 hours: ↓↓mortality if balanced >24 hours: no difference |
|
PROPPR 2015 |
Ratios of RBC:FFP:plt in trauma – 2:1:1 vs 1:1:1 Type: multi-centre RCT Upshot of 1-1-1: ↔Mortality (but underpowered for this) ↓Time to haemostasis ↓Death due to exsanguination |
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TITRe2 2015 |
Hb 7.5 vs 9: elective cardiac surgery Type: multi-centre RCT Upshot of restrictive: -↑Mortality (reason unclear) -↔Ischaemic events |
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TRICS-3 2018 |
Hb 7.9 vs 9.5: high risk cardiac surgery Type: multi-national RCT Subjects: EuroSCORE ≥6 Upshot: no difference in disasters (composite death/AMI/dialysis) |