Vascular trials

GALA 2008

GA vs LA for carotid endarterectomy

Type: multi-centre RCT

Upshot:

-Stroke, AMI, death

-QOL

EVAR 1 2010

EVAR vs open AAA repair

Type: multi-centre RCT

Upshot:

-↓Operative mortality

-↔Mortality overall, aneurysm-related mortality

-↑Graft-related complications

-↑Re-intervention

-↑Cost

EVAR 2 2010

EVAR in inoperable AAA

Upshot:

-↓Aneurysm-related mortality

-All-cause mortality

IMPROVE 2014

EVAR vs open repair of ruptured AAA

Type: multi-centre RCT

Upshot:

-↔Mortality at 30 days

PRESERVE 2017

NAC and bicarbonate for preventing contrast-induced nephropathy

Type: multi-centre, double-blinded, placebo-controlled trial

Upshot:

Death

Dialysis
AKI