2011A15 Describe the functions of the gastric secretions.

 

Cell

Product

Release stimulus

Effect

Chief cell

Pepsinogen -> pepsin

Gastric lipase

↓Gastric pH

↓Intestinal pH

ACh (CNX)

Gastrin

Proteolysis (pepsin)

Lipolysis

Parietal cell

HCl

 

 

 

 

 

 

IF

Gastric peptides

Duo peptides

ACh (CNX)

Gastrin

Histamine

1.Proteolysis

2.Activate pepsin

3.Kill microbes

4.Reduce iron to Fe2+

5.Stimulate pancreatic and biliary secretions

 

Complexes B12 (IF)

G cell

Gastrin

ACh -> GRP

Gastric distension

Gastric peptides

Caffeine, alcohol

↑parietal cell activity

D cell

Somatostatin

Gastric acid

Duodenal acid

GIP, CGRP

↓Chief cell activity

↓Parietal cell activity

E cell

Histamine

ACh

Gastrin

↑parietal cell activity

Mucous neck cell

Mucous

HCO3-

Constitutive (PGE2)

Irritation

Physical barrier

Chemical buffer

 

 

 

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