|
Cell |
Product |
Release stimulus |
Effect |
|
Chief cell |
Pepsinogen -> pepsin Gastric lipase |
↓Gastric pH ↓Intestinal pH ACh (CNX) Gastrin |
Proteolysis (pepsin) Lipolysis |
|
Parietal cell |
HCl
IF |
Gastric peptides Duo peptides ACh (CNX) Gastrin Histamine |
1.Proteolysis 2.Activate pepsin 3.Kill microbes 4.Reduce iron to Fe2+ 5.Stimulate pancreatic and biliary secretions
Complexes B12 (IF) |
|
G cell |
Gastrin |
ACh -> GRP Gastric distension Gastric peptides Caffeine, alcohol |
↑parietal cell activity |
|
D cell |
Somatostatin |
Gastric acid Duodenal acid GIP, CGRP |
↓Chief cell activity ↓Parietal cell activity |
|
E cell |
Histamine |
ACh Gastrin |
↑parietal cell activity |
|
Mucous neck cell |
Mucous HCO3- |
Constitutive (PGE2) Irritation |
Physical barrier Chemical buffer |
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